Share This Paper. Methods Citations. Topics from this paper. Hepatitis C virus Liver diseases Virus Diseases. Hepatitis C, Chronic Phytochemicals.
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Medicinal herbs for hepatitis C virus infection. The Cochrane database of systematic reviews. The animals were liver disorders [6]. Inspite of phenomenal obtained from Gentox laboratories, Hyderabad. However there are several condition. The ethical clearance was beneficial activity in treating hepatic disorders.
Different parts of R. The phytochemical properties of the Experimental design leaves and reported the presence of alkaloids, Ranitidine induced hepatotoxicity indole alkaloids, anthracene glycosides, In this study Male Wistar Albino rats of — anthraquinones, carotenoids, coumarins, gm are taken.
Total of 30 animals are dihydrochalcones, fatty acids, flavonoids, involved. Animals are divided in to six groups as flavones, flavonols, steroids and triterpenoids Group I as Control which receives normal [11]. On the i. Total of 30 animals are involved. Throughout 14 days of bd. On the 8th day, Rhynchosia beddomei methanolic extract 18 h after the dose of drugs, all the animals Sl. In the control group, the significant acute biochemical parameters are comparable with hepatocellular damage and biliary obstruction the standard Liv hepatoprotective drug.
But the group which received the test significantly. All the groups were compared with control group, Paracetamol control group and standard group. In Ranitidine the damaged liver cells in the drug treated model mild to moderate sinusoidal space group. The reputed cells of the intoxicated liver dilatation along with hemorrhages noticed in were reformed. Multiple foci of inflammation and inflammatory cells particularly lymphocytes necrosis noticed in centrilobular region of liver.
In Paracetamol and slight steatosis and cholestasis. Portal tract control rat liver mild to moderate bile duct shows fibrosis, bile duct proliferation and hyperplasia or bile duct proliferation noticed in infiltrate consisting of lymphocytes plasma surrounding the portal region of liver.
In MERB cells, polymorphs and eosinophils. Ranitidine specifically inhibits liver hepatocytes appeared normal, periportal the cytochrome P CYP mixed function and centrilobular region appeared normal but oxidase MFO system. Preliminary phytochemical investigation of Paracetamol acetaminophen is a commonly methanol extract was found to contain and widely used analgesic and antipyretic carbohydrates, flavonoids, phenolic compounds agent.
Hepatotoxic doses of acetaminophen and tannins. Alkaloids, flavonoids and saponins deplete the normal levels of hepatic are known to possess hepatoprotective activity. The glutathione symptoms or death in any of the animals up to protects hepatocytes by combining with the one week and till the end of the study. Thus the reactive metabolite of paracetamol thus drug was considered to be safe. Lipid peroxidation has been significantly in all drug treated groups.
Liver suggested to the vicious process of liver injury cells synthesize various proteins like albumin, due to acetaminophen administration. In the fibrinogen, heapatoglobin, transferrin and present study the elevations in the levels of end antitrypsin. The blood levels of these proteins products of lipid peroxidation in the liver of rat are decreased in extensive liver damage. Serum treated with ranitidine and paracetamol were proteins levels were found to decrease in observed. The increase in malondialdehyde positive control group which was reversed in MDA levels in liver suggests enhanced lipid extract treated group.
Serum enzyme levels are peroxidation leading to tissue damage and not a direct measure of hepatic injury, but failure of antioxidant defense mechanisms to elevated levels are indicative of cellular leakage prevent formation of excessive free radicals and loss of integrity of cell membrane. Thus [18]. Liver photomicrographs of different groups The marker enzyme levels in different group of were shown normal liver control showed animals are measured.
Liver photomicrograph extract treated group. These enzymes prevent generation of In conclusion the results of the present study hydroxyl radical and protect the cellular clearly demonstrate with histopathological constituents from oxidative damage [17]. The phytochemical study revealed the widely distributed in all animal tissues and the presence of flavonoids, tannins phenols. The highest activity is found in the red cells and in flavonoids showed the protective effect of liver the liver.
CAT decomposes hydrogen peroxide in liver injury caused by paracetamol and and protects the tissue from highly reactive ranitidine in rats. The above compounds may hydroxyl radicals.
Therefore the reduction in contribute to presence of hepatoprotective the activity of these enzymes may result in a activity. Reddy JS, Deval G. Evaluation of In vitro isolate, characterize and find out the antioxidant activity of ethanolic extract of mechanism of action of the active compounds Rhynchosia beddomei Baker.
Am J competing interests. Phytomed Clin Ther ; 2: Liver Functions. Pharmacol ; 3 1 : T, Naikwade NS.
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